Dry Skin Linked to Missing Enzyme
Chronic dry skin affects more than 100 million people each year. For most, dry skin usually peaks during the cold winter months. For others, dry skin is an ongoing condition that can sometimes become sensitive or uncomfortable.
Until now, we attributed dry skin to a low level of sebum (oil) in the skin which naturally lubricates the skin. New research suggests that chronically dry skin is due to a deficiency in an enzyme called Caspase-14 – an enzyme that plays an important role in keeping the skin hydrated.
Caspase-14 works by targeting Filaggrin, a structural protein that plays a key role in the proper function of the skin. Caspase-14 and Filaggrin work together to keep moisture levels in the skin functioning properly, however, when Caspase-14 levels are low, that cooperation is compromised, and the skin becomes chronically dry.
Dysfunction of Caspase-14 and other proteins in the skin is still in need of further research and clarification. Yet even while much remains unknown, research is beginning to unveil the complexity of these mechanisms and their implications for skin health. For example, we now know that people with skin conditions like Psoriasis and Eczema often have diminished levels of Caspase-14.
There are lots of factors that can contribute to dry skin such as diet and environmental factors. Research suggests that it is likely that Caspase-14 or missing Flaggrin protein can be aggravated by environmental conditions. Dry environments, including those created by heating systems, and increased exposure to detergents and soaps, may aggravate or worsen the defect.
How one’s environment or exposure to substances may trigger this dysfunction in the skin’s barrier is not clear. In the meantime, there are things you can do to treat dry skin (see related articles below) and new products to try that target Caspase-14 and Filaggrin to produce natural moisturizing function in the skin and help it retain water.
Origins™ has created a special formula designed to help chronic dry skin. Make a Difference Plus promps the skin to produce more Caspase-14 and Filaggrin. This unique forumla also contains other ingredients designed to pull water into the skin – helping to keep it more supple, moist and radiant.